All four sentences have problems!
1.) I like the girl in the room, who is young and beautiful.
I see what you're saying about "who," but from the position of the modifier, it still seems like you're trying to describe the room. If "the girl in the room" clearly refers to a particular person, like "the Queen of Spain," then you could say that the "who" part modifies that whole noun phrase. In a larger context, this could certainly happen. ("There are
...
1.) I like the girl in the room, who is young and beautiful.
I see what you're saying about "who," but from the position of the modifier, it still seems like you're trying to describe the room. If "the girl in the room" clearly refers to a particular person, like "the Queen of Spain," then you could say that the "who" part modifies that whole noun phrase. In a larger context, this could certainly happen. ("There are
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